Recently I have encountered a few instances in which the Windows Update client on a system with Forefront Threat Management Gateway (TMG) 2010 installed is unable to retrieve updates and fails with an error code of 80072EE2.
When this occurs, Malware Inspection and Network Inspection Systems signature updates are received without issue.
To resolve this issue, open an elevated command prompt and enter the following command:
netsh winhttp set proxy localhost:8080
If it is necessary to access HTTP and/or HTTPS web sites or services on your Internal network from the TMG firewall, you will need to configure the proxy bypass list. To learn how, enter the following command:
netsh winhttp set proxy ?
If you need to configure Windows Update on the TMG firewall to work with WSUS, read this blog post on the Forefront TMG product team blog.



Posted by Richard Hicks 
